The Night Warriors arcade game was released in 1995. It is the sequel to Darkstalkers, a fighting game released the previous year. Night Warriors is an update of the original game, adding new moves, new characters and more. Pyron and Huitzil, who were unplayable in the first game, were made selectable here, and two entirely new characters -Donovan and Hsien-Ko -were also added. The anime largely focuses on these characters, along with Morrigan and Demitri, the main characters from the first game.

All of the characters from the game make an appearance in the anime at some point, although a few of them only get to appear in non-speaking roles, where they are quickly defeated and most likely killed by Pyron. Night Warriors was ported to the SEGA Saturn. In 2005, Capcom released Vampire: Darkstalkers Collection for the Playstation 2. This collection contains all of the games in the series, but was unfortunately only released in Japan.